Cloning and Crystal Structure of Hematopoietic Prostaglandin D Synthase
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منابع مشابه
Cloning and Crystal Structure of Hematopoietic Prostaglandin D Synthase
Hematopoietic prostaglandin (PG) D synthase is the key enzyme for production of the D and J series of prostanoids in the immune system and mast cells. We isolated a cDNA for the rat enzyme, crystallized the recombinant enzyme, and determined the three-dimensional structure of the enzyme complexed with glutathione at 2.3 A resolution. The enzyme is the first member of the sigma class glutathione...
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Hematopoietic prostaglandin (PG) D sythase (HPGDS) catalyzes the isomerization of PGH2, a common intermediate of various prostanoids, to PGD2, an inflammatory mediator, in the presence of glutathione (GSH). H-PGDS is activated by Mg, which increases the affinity of the enzyme for GSH and the turnover number. An evolutionary study revealed H-PGDS to be Correspondence/Reprint request: Dr. Yoshihi...
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ژورنال
عنوان ژورنال: Cell
سال: 1997
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(00)80374-8